The Antibiotic Properties of Several Strains of Fungi

A fractions obtained from the culture fluids of a seven fungal species identified as Verticillium albo-atrum; V. lecanii; V. bulbillosum; V. dahliae; Fusarium solani; F. oxysporum, and Aspergillus sclerociarum were shown to contain a compounds with a biological activity against twenty two clinical bacterial strains including eleven isolates of gram positive and other were gram negative. Among tested fungal extracts Verticillium albo-atrum and V. lecanii exhibited significant antibacterial potency. Fractions were clearly more active on Gram-positive cocci than Gram-negative bacilli. Determination, isolation and purified of these fractions were carried out using column and oneand/or two-dimensional thin layer chromatography. IR, NMR, and mass spectrum analysis were used to identify the chemical structures of these active compounds. This study revealed that one isolate of fungal species could contain more than one compound acting as a broad spectrum antibacterial agents where two antibacterial compounds were isolated from V. albo-atrum extract and only one compound isolated from V. lecanii